Nigel Pyne

Professor

Personal Statement

Awards: 1995 Sandoz Prize in Pharmacology (awarded by the British Pharmacological Society)

              2010 Elected Member of Academy of Sciences of the Institute of Bologna (affilated with the University of Bologna, founded in 1690)

              2017 Elected Fellow of the Rotal Society of Biology (FRSB)

 

Research interests

  • Lysolipid (sphingosine 1-phosphate, lysophoshatidic acid) receptor signalling in health and disease with specific focus on cancer and cardiovascular/inflammatory disease
  • Cross talk regulation between lysolipid receptors and growth factor receptors/oncogenes (e.g. PDGFR, HER2, EGFR and TRK A)
  • Translational biology of lysolipids (e.g. drug discovery and biomarker identification)
  • Cyclic AMP/cyclic GMP signalling

The overall aim of research is to investigate the molecular mechanisms by which lysolipid receptors regulate cell biology; to determine how these mechanisms become altered in diseases and to evaluate the potential of receptors and enzymes involved in lysolipid signalling as drugable targets. Techniques in the laboratory range from in vitro cell based assays, imaging, mass spectroscopic analysis and proteomics to in vivo analysis. Recent research in this laboratory has received support from Cancer Research UK, British Heart Foundation, Biotechnology and Biological Sciences Research Council and industry.

175 papers published with an H index of 50 and with ~8000 citations (Google Scholar Citations).

Co-founder of Mironid Ltd

Executive member, SULSA

Head of Research, SIPBS (Aug 2006-Sept 2008)

Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc (various biological science) and MPharm (pharmacy) teaching programmes. Supervision of laboratory based research projects at both undergraduate and postgraduate (PhD) level.

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Publications

(181)
  1. Sphingosine kinase1: a potential therapeutic target in pulmonary arterial hypertension?

    Research output: Contribution to journalComment/debate

  2. Sphingosine 1-phosphate and cancer

    Research output: Contribution to journalLiterature review

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Activities

(162)
  1. 75th Anniversary Special issue honouring Nobel Laurette, Professor R Lefkowitz (Journal)

    Activity: Publication peer-review and editorial workJournal or guest editorship

  2. FASEB Meeting on Lysolipids

    Activity: Participating in or organising an eventOrganiser of major conference

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Nigel Pyne

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